JMV 449 ( —— )

产品货号. M30661 CAS No. 139026-66-7

Potent, metabolically stable neurotensin receptor agonist peptide (IC50 = 0.15 nM for inhibition of [125I]-NT binding to neonatal mouse brain; EC50 = 1.9 nM for contraction of guinea pig ileum). Produces long-lasting hypothermic, neuroprotective and analgesic effects in mice following central administration in vivo.

纯度: >98% (HPLC)

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

规格	价格/人民币	库存	数量
100MG	获取报价	有现货
200MG	获取报价	有现货
500MG	获取报价	有现货

产品询价大包装询价加入购物车

生物学信息

产品名称

JMV 449
注意事项

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
产品简述

Potent, metabolically stable neurotensin receptor agonist peptide (IC50 = 0.15 nM for inhibition of [125I]-NT binding to neonatal mouse brain; EC50 = 1.9 nM for contraction of guinea pig ileum). Produces long-lasting hypothermic, neuroprotective and analgesic effects in mice following central administration in vivo.
产品描述

Potent, metabolically stable neurotensin receptor agonist peptide (IC50 = 0.15 nM for inhibition of [125I]-NT binding to neonatal mouse brain; EC50 = 1.9 nM for contraction of guinea pig ileum). Produces long-lasting hypothermic, neuroprotective and analgesic effects in mice following central administration in vivo.
体外实验

——
体内实验

JMV 449 (120 pmol/mouse; i.c.v) shows analgesic effect. Animal Model:Male Swiss albino mice Dosage:120 pmol/mouse Administration:i.c.v.Result:Showed dose-response relation-ships for the analgesic effect.
同义词

——
通路

GPCR/G Protein
靶点

Neurotensin Receptor
受体

——
研究领域

——
适应症

——

化学信息

CAS Number

139026-66-7
分子量

746.96
分子式

C38H66N8O7
纯度

>98% (HPLC)
溶解度

water:0.80 mg/mL
SMILES

[H]N[C@@H](CCCCN)CN[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC1=CC=C(O)C=C1)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC(C)C)C(O)=O
化学全称

——

运输与储存

储存条件

(-20℃)
运输条件

With Ice Pack
稳定性

≥ 2 years

参考文献

1. Lugrin et al (1991) Reduced peptide bond pseudopeptide analogues of neurotensin: binding and biological activities, and in vitro metabolic stability. Eur.J.Pharmacol. 205 191 PMID:

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摩尔计算器

分子量计算器

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